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Pentobarbital was used in a U.S. execution for The 1st time in December 2010 in Oklahoma, as part of a three-drug protocol.[16] In March 2011 pentobarbital was used for The 1st time as the only drug inside of a U.S. execution, in Ohio. Given that then several states as well as the federal govt have employed pentobarbital for lethal injections; some